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	Provedor de dados Biol. Res. (1) BJMBR (1) Autor Bukauskas,F.F. (1) CAVIEDES,PABLO (1) CAVIEDES,RAÚL (1) RAPOPORT,STANLEY I (1) Trexler,E.B. (1) Verselis,V.K. (1) Mais... Palavra-chave Patch clamp (2) Calcium current (1) Channel gating (1) Connexin46 (1) Dorsal root ganglion (1) Down syndrome (1) Permeability (1) Tissue culture (1) Trisomy 16 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2006 (1) 2000 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Altered calcium currents in cultured sensory neurons of normal and trisomy 16 mouse fetuses, an animal model for human trisomy 21 (Down Syndrome) Biol. Res. CAVIEDES,PABLO; CAVIEDES,RAÚL; RAPOPORT,STANLEY I. Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical membrane properties of fetal dorsal root ganglia (DRG) neurons, as in the trisomy 16 fetal mouse, an animal model of the human condition. Cultured trisomic DRG neurons from human and mouse fetuses present faster rates of depolarization and repolarization in the action potential compared to normal controls and a shorter spike duration. Also, trisomy 16 brain and spinal cord tissue exhibit reduced acetylcholine secretion. Therefore, we decided to study Ca2+ currents in cultured DRG neurons from trisomy 16 and age-matched control mice, using... Tipo: Journal article Palavras-chave: Trisomy 16; Dorsal root ganglion; Calcium current; Tissue culture; Patch clamp; Down syndrome. Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300009 Connexin hemichannels and cell-cell channels: comparison of properties BJMBR Verselis,V.K.; Trexler,E.B.; Bukauskas,F.F.. Connexin46 (Cx46) forms functional hemichannels in the absence of contact by an apposed hemichannel and we have used these hemichannels to study gating and permeation at the single channel level with high time resolution. Using both cell-attached and -excised patch configurations, we find that single Cx46 hemichannels exhibit some properties expected of half of a gap junction channel, as well as novel properties. Cx46 hemichannels have a large unitary conductance (~300 pS) and a relatively large pore as inferred from permeability to TEA. Both monovalent cations and anions can permeate, but cations are substantially more permeable. The open channel conductance shows marked inward rectification in symmetric salts. We find that the conductance and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Permeability; Channel gating; Connexin46; Patch clamp. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400003 Registros recuperados: 2 Primeira ... 1 ... Última

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